
Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass: Cell Reports
Ye et al. show that energy regulation differs between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) where only RYGB enhances splanchnic nerve activity, to induce visceral fat thermogenesis, and increases resting metabolic rate (RMR). This sympathetic-mediated “browning” of visceral fat seems to be dependent on endocannabinoid receptor-1 (CB1) signaling.